| Bioactivity | 17-HETE is arachidonic acid metabolite through cytochrome P-450 pathways, which consists of 17R-HETE and 17S-HETE enantiomers. 17-HETE serves as allosteric activator of the cytochrome P450 1B1 and inhibitor of ATPase, induces cardic hypertrophy[1][2]. |
| Invitro | 17-HETE (5-20 μM) 通过促进 CY1B1 的活性和蛋白质水平来促进人心脏肥大的发展[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 17-HETE 相关抗体: Real Time qPCR[1] Cell Line: |
| In Vivo | 17-HETE (1-20 μg，动脉注射) 立体特异性地 (S-对映异构体) 抑制新西兰白兔的近端小管 ATP 酶活性[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 128914-47-6 |
| Formula | C20H32O3 |
| Molar Mass | 320.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Isse FA, et al., 17-(R/S)-hydroxyeicosatetraenoic acid (HETE) induces cardiac hypertrophy through the CYP1B1 in enantioselective manners. Prostaglandins Other Lipid Mediat. 2023 Oct;168:106749. [2]. Carroll MA, e al., Cytochrome P-450-dependent HETEs: profile of biological activity and stimulation by vasoactive peptides. Am J Physiol. 1996 Oct;271(4 Pt 2):R863-9. |