15-Deoxy-Δ12,14-prostaglandin A1_product_DataBase

Bioactivity	15-Deoxy-Δ12,14-prostaglandin A1 is a deoxyanalog of prostaglandins that inhibits NF-κB signaling and induces apoptosis. 15-Deoxy-Δ12,14-prostaglandin A1 inhibits TNF-α-induced upregulation of inflammatory endothelial cell adhesion molecule (CAM) and avoids monocyte arrest[1].
Invitro	15-Deoxy-Δ12,14-prostaglandin A1 (25, 50 μM; 2 h) 抑制 TNF-α 诱导的 IκB-α 激酶 (IKK) 激活、IκB-α 降解和 NF-κB/p65 易位，同时促进 AP-1/c-Jun 磷酸化[1]。15-Deoxy-Δ12,14-prostaglandin A1 (25 μM; 2 h) 可增强 TNF-α 诱导的 HAEC 和 HUVEC 细胞死亡[1]。15-Deoxy-Δ12,14-prostaglandin A1 (10 μM; 2 h) 抑制 TNF-α 诱导的单核细胞阻滞[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 15-Deoxy-Δ12,14-prostaglandin A1 相关抗体: Cell Viability Assay[1] Cell Line:
CAS	573951-20-9
Formula	C20H30O3
Molar Mass	318.45
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zernecke A, et al. Suppression of endothelial adhesion molecule up-regulation with cyclopentenone prostaglandins is dissociated from IkappaB-alpha kinase inhibition and cell death induction. FASEB J. 2003 Jun;17(9):1099-101.

PeptideDB