15-A2t-Isoprostane_product_DataBase

Bioactivity	15-A2t-Isoprostane (8-iso Prostaglandin A2) is an isoprostaglandin produced by the non-enzymatic oxidation of arachidonic acid[1][2][3].
Invitro	15-A2t-Isoprostane (10, 30 μM, 3 h) 增强了谷氨酸诱导的细胞毒性，降低了 HT22 海马细胞中的谷胱甘肽 (GSH) 水平[2]。15-A2t-Isoprostane (10 μM, 24 h) 可抑制 VEGF 诱导的人冠状动脉内皮细胞的迁移和小管形成[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 15-A2t-Isoprostane 相关抗体:
CAS	474391-66-7
Formula	C20H30O4
Molar Mass	334.45
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Chen Y, et al. Formation of reactive cyclopentenone compounds in vivo as products of the isoprostane pathway. J Biol Chem. 1999 Apr 16;274(16):10863-8. [2]. Musiek ES, et al. Cyclopentenone isoprostanes are novel bioactive products of lipid oxidation which enhance neurodegeneration. J Neurochem. 2006 Jun;97(5):1301-13. [3]. Benndorf RA, et al. Isoprostanes inhibit vascular endothelial growth factor-induced endothelial cell migration, tube formation, and cardiac vessel sprouting in vitro, as well as angiogenesis in vivo via activation of the thromboxane A(2) receptor: a potential link between oxidative stress and impaired angiogenesis. Circ Res. 2008 Oct 24;103(9):1037-46.

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