| Bioactivity | 1-NBX is a potent and selective A1R ligand. 1-NBX exhibits significantly improved A1R affinity with with a Ki of 2.6 nM and lower affinity for the A2A receptor with a Ki of 164 nM. [18F]1-NBX acts as a promising candidate for further preclinical evaluation as potential PET tracer for A1R imaging[1]. |
| Formula | C18H25FN4O2 |
| Molar Mass | 348.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Swen Humpert, et al. 8-Bicycloalkyl-CPFPX derivatives as potent and selective tools for in vivo imaging of the A1 adenosine receptor. Eur J Med Chem. 2024 Apr 6:271:116380. |