| Bioactivity | (S)-Norzopiclone ((S)-N-Desmethyl zopiclone; SEP-174559) is a metabolite of Zopiclone with anxiolytic and anticonvulsant effects. (S)-Norzopiclone has benzodiazepine-like actions at γ2-bearing subtypes of the GABAA receptor and inhibits nACh and NMDA receptors[1]. |
| Invitro | Micromolar concentrations of (S)-Norzopiclone (SEP-174559) potentiates GABAA receptor currents evoked by subsaturating concentrations of GABA[1]. (S)-Norzopiclone9 is not selective between alpha1-, alpha2-, or alpha3-bearing GABAA receptors. Within the nicotinic receptor superfamily, (S)-Norzopiclone does not affect serotonin type-3 receptor function but is found to inhibit nACh receptors[1].In the glutamate receptor superfamily, (S)-Norzopiclone inhibits N-methyl-D-aspartate (NMDA) receptor currents but does not affect non-NMDA receptors[1]. |
| Name | (S)-Norzopiclone |
| CAS | 151776-26-0 |
| Formula | C16H15ClN6O3 |
| Molar Mass | 374.78 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mark W Fleck. Molecular actions of (S)-desmethylzopiclone (SEP-174559), an anxiolytic metabolite of zopiclone. J Pharmacol Exp Ther. 2002 Aug;302(2):612-8. |
(S)-Norzopiclone
CAS: 151776-26-0 F: C16H15ClN6O3 W: 374.78
(S)-Norzopiclone ((S)-N-Desmethyl zopiclone; SEP-174559) is a metabolite of Zopiclone with anxiolytic and anticonvulsant
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