(Rac)-Etavopivat_product_DataBase

CAS: 2622070-93-1 F: C22H23N3O6S W: 457.50

(Rac)-Etavopivat ((Rac)-FT-4202) is an isomer of Etavopivat (HY-139573). Etavopivat is an orally active erythrocyte pyru

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Bioactivity

(Rac)-Etavopivat ((Rac)-FT-4202) is an isomer of Etavopivat (HY-139573). Etavopivat is an orally active erythrocyte pyruvate kinase-R (PKR) activator that can be used in studies of sickle cell disease and other haemoglobinopathies[1].

Invitro

Etavopivat (20 μM, 4 h)可以改善人红细胞中血红蛋白-氧亲和力并降低了镰状点 (PoS)[1]。

In Vivo

Etavopivat（口服，3-22mg/kg，每天一次，5天）在 8 mg/kg和 22 mg/kg 的剂量下引起食蟹猴 2,3-DPG 和 ATP 的增加[1]。

Name

(Rac)-Etavopivat

CAS

2622070-93-1

Formula

C22H23N3O6S

Molar Mass

457.50

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Patricia Schroeder, et al. Etavopivat, a Pyruvate Kinase Activator in Red Blood Cells, for the Treatment of Sickle Cell Disease. J Pharmacol Exp Ther. 2022 Mar;380(3):210-219.

PeptideDB

(Rac)-Etavopivat

CAS: 2622070-93-1 F: C22H23N3O6S W: 457.50