| Bioactivity | (R,S,R)-ML334 is the inactive isomer of ML334 (HY-110258), and can be used as an experimental control. ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity[1][2]. |
| Name | (R,S,R)-ML334 |
| CAS | 1432065-33-2 |
| Formula | C26H26N2O5 |
| Molar Mass | 446.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wen X, et al. Activation of NRF2 Signaling in HEK293 Cells by a First-in-Class Direct KEAP1-NRF2 Inhibitor. J Biochem Mol Toxicol. 2015 Jun;29(6):261-6. [2]. Hu L, et al. Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem Lett. 2013 May 15;23(10):3039-43. |
(R,S,R)-ML334
CAS: 1432065-33-2 F: C26H26N2O5 W: 446.50
(R,S,R)-ML334 is the inactive isomer of ML334 (HY-110258), and can be used as an experimental control. ML334 is a potent
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