| Bioactivity | (7R)-SBP-0636457 is the inactive isomer of SBP-0636457 (HY-125378), and can be used as an experimental control. SBP-0636457 (SB1-0636457) is a SMAC mimetic, and as an IAP antagonist. SBP-0636457 binds to the BIR-domains of the IAP proteins, with a Ki of 0.27 μM. SBP-0636457 can be used for the research of solid tumors and hematologic cancers[1][2]. |
| Name | (7R)-SBP-0636457 |
| CAS | 1422180-61-7 |
| Formula | C25H36N4O4 |
| Molar Mass | 456.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Finlay D, et, al. Small-molecule IAP antagonists sensitize cancer cells to TRAIL-induced apoptosis: roles of XIAP and cIAPs. Mol Cancer Ther. 2014 Jan; 13(1): 5-15. [2]. Finlay D, et, al. Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins. F1000Res. 2017 Apr 27; 6:587. |
(7R)-SBP-0636457
CAS: 1422180-61-7 F: C25H36N4O4 W: 456.58
(7R)-SBP-0636457 is the inactive isomer of SBP-0636457 (HY-125378), and can be used as an experimental control. SBP-0636
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