(R)-SKF 38393 hydrochloride

CAS: 81702-42-3 F: C16H18ClNO2 W: 291.77

(R)-SKF 38393 ((±)-SKF-38393) hydrochloride is a potent and selective D1 dopamine receptor antagonist. (R)-SKF 38393 hy

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Bioactivity	(R)-SKF 38393 ((±)-SKF-38393) hydrochloride is a potent and selective D1 dopamine receptor antagonist. (R)-SKF 38393 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channel[1].
Invitro	(R)-SKF 38393 HydroHClide ((±)-SKF-38393; 0-100 µM) 阻断 AtT-20 细胞中由生长抑素或 D3 多巴胺受体诱导的内源 GIRK 电流，IC50 值为 268 nM[1]。
Name	(R)-SKF 38393 hydrochloride
CAS	81702-42-3
Formula	C16H18ClNO2
Molar Mass	291.77
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Kuzhikandathil EV, et, al. Classic D1 dopamine receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupled inwardly rectifying potassium channels. Mol Pharmacol. 2002 Jul;62(1):119-26.