| Bioactivity | Excisanin A is a potent anticancer agent. Excisanin A inhibits cell proliferation, migration, adhesion and invasion. Excisanin A decreases the expression of MMP-2, MMP-9, p-FAK, p-Src, integrin β1 protein. Excisanin A has the potential for the research of breast cancer[1]. |
| Invitro | Excisanin A (5-80 µM；24、48、72 小时) 在 MDA-MB-231、SKBR3 细胞中显示出时间和剂量依赖性的抗增殖活性[1]。Excisanin A (10、20、40 µM；24 小时) 抑制 MDA-MB-231、SKBR3 细胞的细胞迁移、粘附和侵袭[1]。Excisanin A (10, 20, 40 µM; 24 h) 以剂量依赖性方式降低 MDA-MB-231 细胞中 MMP-2、MMP-9、p-FAK、p-Src、整合素 β1 蛋白的表达[1]。 Cell Proliferation Assay[1] Cell Line: |
| Name | Excisanin A |
| CAS | 78536-37-5 |
| Formula | C20H30O5 |
| Molar Mass | 350.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Qin J, et al. A diterpenoid compound, excisanin A, inhibits the invasive behavior of breast cancer cells by modulating the integrin β1/FAK/PI3K/AKT/β-catenin signaling. Life Sci. 2013 Nov 4;93(18-19):655-63. |