| Bioactivity | (R)-Birabresib is the inactive isomer of Birabresib (HY-15743), and can be used as an experimental control. Birabresib (OTX-015) is a potent bromodomain (BRD2/3/4) inhibitor with IC50s ranging from 92 to 112 nM. | ||||||||||||
| Name | (R)-Birabresib | ||||||||||||
| CAS | 1983196-25-3 | ||||||||||||
| Formula | C25H22ClN5O2S | ||||||||||||
| Molar Mass | 491.99 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Marie-Magdelaine Coudé, et al. BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells. Oncotarget. 2015 Jul 10; 6(19): 17698–17712. [2]. Lu P, et al. The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb. Sci Rep. 2016 Apr 12;6:24100 [3]. Vázquez R, et al. The bromodomain inhibitor OTX015 (MK-8628) exerts anti-tumor activity in triple-negative breast cancer models as single agent and in combination with RAD001. Oncotarget. 2017 Jan 31;8(5):7598-7613. [4]. J. Kay Noel, et al. Abstract C244: Development of the BET bromodomain inhibitor OTX015. Mol Cancer Ther November 2013 12; C244. |
(R)-Birabresib
CAS: 1983196-25-3 F: C25H22ClN5O2S W: 491.99
(R)-Birabresib is the inactive isomer of Birabresib (HY-15743), and can be used as an experimental control. Birabresib (
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