| Bioactivity | (Gly14)-Humanin (human) (14-Glycine-Humanin (human)) acetate is an analog of Humanin in which the 14th amino acid serine was replaced with glycine (Gly). (Gly14)-Humanin (human) acetate has anti-apoptotic and neuroprotective functions[1][2]. | ||||||
| Invitro | (Gly14)-Humanin (human) acetate (0.1-10 μM; 72 hours) 显着增加细胞活力，降低 HUVEC 的核荧光、裂解 PARP 水平、ROS 形成和 bax/bcl-2 比值 。并降低 bax 的mRNA水平，增加 bcl-2 的 mRNA 水平[1]。 | ||||||
| In Vivo | (Gly14)-Humanin (human) acetate（0.1 μg/5 μL；i.c.v.；一次）减少受损皮层和海马体中具有质膜通透性的细胞，减少脑损伤体积，改善运动性能并改善莫里斯水迷宫试验中的性能[2]。 | ||||||
| Name | (Gly14)-Humanin (human) (acetate) | ||||||
| Sequence | Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala | ||||||
| Shortening | MAPRGFSCLLLLTGEIDLPVKRRA | ||||||
| Formula | C118H202N34O31S2.xC2H4O2 | ||||||
| Molar Mass | 2657.21 (free acid) | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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| Reference | [1]. Ying Xie, et al. Protection effect of [Gly14]-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells. Diabetes Res Clin Pract. 2014 Dec;106(3):560-6. [2]. T Wang, et al. [Gly14]-Humanin reduces histopathology and improves functional outcome after traumatic brain injury in mice. Neuroscience. 2013 Feb 12;231:70-81. |
(Gly14)-Humanin (human) (acetate)
CAS: F: C118H202N34O31S2.xC2H4O2 W: 2657.21 (free acid)
(Gly14)-Humanin (human) (14-Glycine-Humanin (human)) acetate is an analog of Humanin in which the 14th amino acid serine
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