| Bioactivity | (E)-2-Hexadecenal is an MLK3 activator that induces cytoskeletal remodeling, leading to cell rounding, detachment, and ultimately apoptosis in human and mouse cells. (E)-2-Hexadecenal activates the MLK3 signaling pathway, phosphorylating MKK4/7 and JNK, subsequently activating downstream targets of JNK, such as c-Jun phosphorylation, cytochrome c release, Bax activation, Bid cleavage, and Bim translocation to mitochondria. (E)-2-Hexadecenal has potential applications in research related to sphingolipid signaling pathways[1]. |
| CAS | 22644-96-8 |
| Formula | C16H30O |
| Molar Mass | 238.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kumar A, et al. The sphingolipid degradation product trans-2-hexadecenal induces cytoskeletal reorganization and apoptosis in a JNK-dependent manner. Cell Signal. 2011 Jul;23(7):1144-52. |
(E)-2-Hexadecenal
CAS: 22644-96-8 F: C16H30O W: 238.41
(E)-2-Hexadecenal is an MLK3 activator that induces cytoskeletal remodeling, leading to cell rounding, detachment, and u
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