| Bioactivity | (4-NH2)-Exatecan-d5 is a deuterated labeled (4-NH2)-Exatecan[1]. (4-NH2)-Exatecan (compound A), a topoisomerase inhibitor, is a derivative of Exatecan. (4-NH2)-Exatecan can be used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
| Invitro | 氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。(4-NH2)-Exatecan 含有用于连接配体单元的接头，其中接头以可裂解的方式连接至氨基残基，其特征在于在母体的第 4 位添加氨基 (NH2) 官能团分子[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> (4-NH2)-Exatecan-d5 相关抗体: |
| Formula | C23H16D5N3O4 |
| Molar Mass | 408.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Howard PW, et, al. Compounds and conjugates thereof. US20200306243A1. |