| Bioactivity | (3S,5S,6R)-Navtemadlin is the inactive isomer of Navtemadlin (HY-12296), and can be used as an experimental control. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC50 of 0.6 nM. Navtemadlin binds to MDM2 with a Kd of 0.045 nM[1][2]. |
| Name | (3S,5S,6R)-Navtemadlin |
| CAS | 2459946-14-4 |
| Formula | C28H35Cl2NO5S |
| Molar Mass | 568.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Canon J, et al. The MDM2 Inhibitor AMG 232 Demonstrates Robust Antitumor Efficacy and Potentiates the Activity of p53-Inducing Cytotoxic Agents. Mol Cancer Ther. 2015 Mar;14(3):649-58. [2]. Rew Y, et al. Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer. J Med Chem. 2014 Aug 14;57(15):6332-41. |
(3S,5S,6R)-Navtemadlin
CAS: 2459946-14-4 F: C28H35Cl2NO5S W: 568.55
(3S,5S,6R)-Navtemadlin is the inactive isomer of Navtemadlin (HY-12296), and can be used as an experimental control. Nav
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