(3S,5S)-Atorvastatin_product_DataBase

Bioactivity

(3S,5S)-Atorvastatin is a inactive enantiomer of Atorvastatin. (3S,5S)-Atorvastatin can activate pregnane X receptor (PXR). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1][2].

Target

Pregnane X receptor (PXR)

Invitro

Atorvastatin and its inactive enantiomer (3S,5S)-Atorvastatin increases CYP2B and CYP3A mRNA content with equal ability[1].(3S,5S)-Atorvastatin in 100 μM concentrations induces luciferase activity with an EC50 of 12.4 μM[2].Addition of (3S,5S)-Atorvastatin to the 2-formylphenylboronicacid (FPBA)/l-tryptophanol mixture induces an intensity enhancement of l-tryptophanol florescence[3].

Name

(3S,5S)-Atorvastatin

CAS

501121-34-2

Formula

C33H35FN2O5

Molar Mass

558.64

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Thomas A Kocarek, et al. Regulation of CYP2B6 and CYP3A Expression by Hydroxymethylglutaryl Coenzyme A Inhibitors in Primary Cultured Human Hepatocytes. Drug Metab Dispos. 2002 Dec;30(12):1400-5. [2]. Martina Korhonova, et al. Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes. PLoS One. 2015 Sep 14;10(9):e0137720. [3]. Elena G Shcherbakova , et al. High-Throughput Assay for Enantiomeric Excess Determination in 1,2- And 1,3-Diols and Direct Asymmetric Reaction Screening. Chemistry. 2017 Jul 26;23(42):10222-10229.

PeptideDB

(3S,5S)-Atorvastatin

CAS: 501121-34-2 F: C33H35FN2O5 W: 558.64