| Bioactivity | (1R,2R)-Calhex 231 hydrochloride is the inactive isomer of Calhex 231 hydrochloride (HY-103320A), and can be used as an experimental control. Calhex 231 hydrochloride is a CaSR inhibitor via negative allosteric modulation. Calhex 231 hydrochloride blocks Ca2+-induced accumulation of [3H]inositol phosphate with an IC50 of 0.39 μM in HEK293 cells. Calhex 231 hydrochloride has the potential for diabetic cardiomyopathy (DCM) treatment[1][2]. |
| Name | (1R,2R)-Calhex 231 hydrochloride |
| Formula | C25H28Cl2N2O |
| Molar Mass | 443.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yuan H, et al. Calhex231 Alleviates High Glucose-Induced Myocardial Fibrosis via Inhibiting Itch-Ubiquitin Proteasome Pathway in Vitro. Biol Pharm Bull. 2019 Aug 1;42(8):1337-1344. [2]. Petrel C1, et al. Modeling and mutagenesis of the binding site of Calhex 231, a novel negative allosteric modulator of the extracellular Ca(2+)-sensing receptor. J Biol Chem. 2003 Dec 5;278(49):49487-94. |
(1R,2R)-Calhex 231 hydrochloride
CAS: F: C25H28Cl2N2O W: 443.41
(1R,2R)-Calhex 231 hydrochloride is the inactive isomer of Calhex 231 hydrochloride (HY-103320A), and can be used as an
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.