Bioactivity | (+)-LRH-1 modulator-1 is a stereoisomer of LRH-1 modulator-1. LRH-1 modulator-1 (compound 6N) is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. LRH-1 modulator-1 has anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 induces the anti-inflammatory cytokine IL-10 and reduces the inflammatory cytokines IL-1b and TNFa[1]. | |||||||||
Formula | C28H36N2O2S | |||||||||
Molar Mass | 464.66 | |||||||||
Appearance | 油状物 | |||||||||
Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
Storage |
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Reference | [1]. Mays S G, et al. Development of the first low nanomolar liver receptor homolog-1 agonist through structure-guided design[J]. Journal of medicinal chemistry, 2019, 62(24): 11022-11034. |