(±)-Penbutolol ((Rac)-Penbutolol) is the racemic form of Penbutolol. (±)-Penbutolol is an orally active β-adrenergic receptor antagonist. (±)-Penbutolol antagonizes exercise-induced tachycardia, reduces exercise-induced increases in peak expiratory flow (PEFR), and reduces resting renin activity (PRA). (±)-Penbutolol reaches peak plasma concentration 1 hour after oral administration, has a half-life of 4.5 hours, and is converted into active metabolites in the body. (±)-Penbutolol can be used in the study of cardiovascular-related diseases.

Physicochemical Properties

Molecular Formula	C18H29NO2
Molecular Weight	291.43
CAS #	36507-48-9
Related CAS #	(±)-Penbutolol-d9;1346747-40-7;(±)-Penbutolol-d9 hydrochloride;1346605-01-3
SMILES	CC(C)(C)NCC(COC1=CC=CC=C1C2CCCC2)O
Synonyms	(Rac)-Penbutolol; (±)-Isopenbutolol
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Beta-1 adrenergic receptor
References	[1]. Comparative beta-adrenoceptor blocking effects and pharmacokinetics of penbutolol and propranolol in man. Br J Clin Pharmacol. 1977 Apr;4(2):135-40.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.4314 mL	17.1568 mL	34.3136 mL
	5 mM	0.6863 mL	3.4314 mL	6.8627 mL
	10 mM	0.3431 mL	1.7157 mL	3.4314 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.