PKMYT1-IN-8 (Compound 137) is an inhibitor of PKMYT1 with IC50 of 9 nM. PKMYT1-IN-8 can also inhibit EPHB3, EPHA1, KIT, EPHB1, EPHA2, EPHA3 and EPHB2 with IC50 of 1.79, 3.17, 4.29, 6.32, 6.83, 8.10 and 10.9 μM, respectively. PKMYT1-IN-8 can inhibit the proliferation of cancer cell OVCAR3 with GI50 of 2.02 μM.

Physicochemical Properties

Molecular Formula	C17H16F3N5O2
Molecular Weight	379.34
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Pyrrolopyrimidinecarboxamides as PKMYT1 inhibitors and their preparation. WO2024252276.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.6362 mL	13.1808 mL	26.3616 mL
	5 mM	0.5272 mL	2.6362 mL	5.2723 mL
	10 mM	0.2636 mL	1.3181 mL	2.6362 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.