Neomangiferin is a naturally occurring C-glucosyl xanthone isolated from Anemarrhena asphodeloides with the potential to be used to treat inflammation, asthma, and pain. May also be used high-fat diet-induced nonalcoholic fatty liver disease (NAFLD).
Physicochemical Properties
| Molecular Formula | C25H28O16 |
| Molecular Weight | 584.4802 |
| Exact Mass | 584.138 |
| CAS # | 64809-67-2 |
| PubChem CID | 6918448 |
| Appearance | White to light yellow solid powder |
| Density | 1.839 |
| Boiling Point | 1026.377ºC at 760 mmHg |
| Flash Point | 343.913ºC |
| Index of Refraction | 1.76 |
| LogP | -2.2 |
| Hydrogen Bond Donor Count | 11 |
| Hydrogen Bond Acceptor Count | 16 |
| Rotatable Bond Count | 5 |
| Heavy Atom Count | 41 |
| Complexity | 924 |
| Defined Atom Stereocenter Count | 10 |
| SMILES | C1=C2C(=CC(=C1O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)O)OC4=C(C2=O)C(=C(C(=C4)O)[C@H]5[C@@H]([C@H]([C@@H]([C@H](O5)CO)O)O)O)O |
| InChi Key | VUWOVGXVRYBSGI-IRXABLMPSA-N |
| InChi Code | InChI=1S/C25H28O16/c26-4-12-17(31)20(34)22(36)24(39-12)14-8(29)3-11-15(19(14)33)16(30)6-1-10(7(28)2-9(6)38-11)40-25-23(37)21(35)18(32)13(5-27)41-25/h1-3,12-13,17-18,20-29,31-37H,4-5H2/t12-,13-,17-,18-,20+,21+,22-,23-,24+,25-/m1/s1 |
| Chemical Name | 1,3,6-trihydroxy-2-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-7-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyxanthen-9-one |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage. |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| References |
[1]. Quantification of neomangiferin in rat plasma by liquid chromatography-tandem mass spectrometry and its application to bioavailability study.J Pharm Anal. 2016 Oct;6(5):335-340. |
| Additional Infomation |
Neomangiferin is a member of xanthones. Neomangiferin has been reported in Anemarrhena asphodeloides and Metagentiana rhodantha with data available. |
Solubility Data
| Solubility (In Vitro) | DMSO : ~100 mg/mL (~171.09 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (4.28 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (4.28 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7109 mL | 8.5546 mL | 17.1092 mL | |
| 5 mM | 0.3422 mL | 1.7109 mL | 3.4218 mL | |
| 10 mM | 0.1711 mL | 0.8555 mL | 1.7109 mL |