Myristoyl glutamic acid sodium, a form of myristoyl glutamic acid, is a common ingredient in cosmetics/face creams. Myristoyl glutamic acid sodium is an amino acid (AA) surfactant with mild cleaning ability, foaming and slight antibacterial functions.

Physicochemical Properties

Molecular Formula	C19H34NNAO5
Molecular Weight	379.47
Exact Mass	379.233
CAS #	38517-37-2
PubChem CID	23682081
Appearance	Typically exists as solid at room temperature
LogP	3.177
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	17
Heavy Atom Count	26
Complexity	390
Defined Atom Stereocenter Count	1
SMILES	[Na+].CCCCCCCCCCCCCC(N[C@H](C([O-])=O)CCC(=O)O)=O
InChi Key	ZNYIJXQYUNSKDX-NTISSMGPSA-M
InChi Code	InChI=1S/C19H35NO5.Na/c1-2-3-4-5-6-7-8-9-10-11-12-13-17(21)20-16(19(24)25)14-15-18(22)23;/h16H,2-15H2,1H3,(H,20,21)(H,22,23)(H,24,25);/q;+1/p-1/t16-;/m0./s1
Chemical Name	sodium;(2S)-5-hydroxy-5-oxo-2-(tetradecanoylamino)pentanoate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Face cream cleansers.

Solubility Data

Solubility (In Vitro)

DMSO : 2.5 mg/mL (6.59 mM) DMF : < 1 mg/mL

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 0.25 mg/mL (0.66 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 2.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 0.25 mg/mL (0.66 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 2.5 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 0.25 mg/mL (0.66 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 2.5 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.6353 mL	13.1763 mL	26.3525 mL
	5 mM	0.5271 mL	2.6353 mL	5.2705 mL
	10 mM	0.2635 mL	1.3176 mL	2.6353 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.