MAT2A-IN-9 (compound 167) is a 2-oxoquinazoline analogue and a potent MAT2A (methionine adenosyltransferase 2A) inhibitor.

Physicochemical Properties

Molecular Formula	C14H8CLF3N4O
Molecular Weight	340.687731742859
Exact Mass	340.033
CAS #	2439277-80-0
PubChem CID	153608878
Appearance	Typically exists as solid at room temperature
LogP	2.7
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Heavy Atom Count	23
Complexity	513
Defined Atom Stereocenter Count	0
InChi Key	BVNKURJMNQNVAO-UHFFFAOYSA-N
InChi Code	InChI=1S/C14H8ClF3N4O/c15-8-3-1-2-4-9(8)22-12-7(11(19)21-13(22)23)5-6-10(20-12)14(16,17)18/h1-6H,(H2,19,21,23)
Chemical Name	4-amino-1-(2-chlorophenyl)-7-(trifluoromethyl)pyrido[2,3-d]pyrimidin-2-one
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	MAT2A[1]
References	[1]. Muzaffar Alam, et al. 2-oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors. WO2020123395A1.

Solubility Data

Solubility (In Vitro)

DMSO : 100 mg/mL (293.52 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 1 mg/mL (2.94 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.9352 mL	14.6761 mL	29.3522 mL
	5 mM	0.5870 mL	2.9352 mL	5.8704 mL
	10 mM	0.2935 mL	1.4676 mL	2.9352 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.