Gallic aldehyde is an HSV-1 inhibitor extracted from Geum japonicum and has potent anti-viral effect.

Physicochemical Properties

Molecular Formula	C7H6O4
Molecular Weight	154.12
Exact Mass	154.026
CAS #	13677-79-7
PubChem CID	83651
Appearance	White to light brown solid powder
Density	1.6±0.1 g/cm3
Boiling Point	355.3±37.0 °C at 760 mmHg
Melting Point	211-213°C
Flash Point	182.9±23.0 °C
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.734
LogP	0.9
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Heavy Atom Count	11
Complexity	135
Defined Atom Stereocenter Count	0
InChi Key	RGZHEOWNTDJLAQ-UHFFFAOYSA-N
InChi Code	InChI=1S/C7H6O4/c8-3-4-1-5(9)7(11)6(10)2-4/h1-3,9-11H
Chemical Name	3,4,5-trihydroxybenzaldehyde
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. A New Hydrolyzable Tannin from Geum japonicum and Its Antiviral Activity. Heterocycles, 1994, 38(1):167-175.
Additional Infomation	3,4,5-Trihydroxybenzaldehyde has been reported in Lens culinaris, Geum japonicum, and other organisms with data available.

Solubility Data

Solubility (In Vitro)

DMSO : 125 mg/mL (811.06 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (13.50 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.08 mg/mL (13.50 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.4885 mL	32.4423 mL	64.8845 mL
	5 mM	1.2977 mL	6.4885 mL	12.9769 mL
	10 mM	0.6488 mL	3.2442 mL	6.4885 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.