ER-DRI is a potent peptide inhibitor targeting EV-A71. ER-DRI directly binds to 3A and specifically eliminates the activity of RNAi viral suppressors, thereby unlocking the antiviral RNAi response that is suppressed by 3A. ER-DRI also effectively inhibits another RNAi-dependent enterovirus, Coxsackievirus-A16.

Physicochemical Properties

Molecular Formula	C118H201N49O30S
Molecular Weight	2818.23
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Inhibition of viral suppressor of RNAi proteins by designer peptides protects from enteroviral infection in vivo. Immunity. 2021 Oct 12;54(10):2231-2244.e6.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.3548 mL	1.7742 mL	3.5483 mL
	5 mM	0.0710 mL	0.3548 mL	0.7097 mL
	10 mM	0.0355 mL	0.1774 mL	0.3548 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.