EGFR PTK (protein tyrosine kinase) Substrate is a substrate of EGFR tyrosine kinase.

Physicochemical Properties

Molecular Formula	C48H73N11O17
Molecular Weight	1076.15673232079
Exact Mass	1075.518
CAS #	945830-38-6
PubChem CID	162678811
Appearance	White to off-white solid powder
LogP	-4.5
Hydrogen Bond Donor Count	14
Hydrogen Bond Acceptor Count	18
Rotatable Bond Count	33
Heavy Atom Count	76
Complexity	2100
Defined Atom Stereocenter Count	10
SMILES	C(N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@H](C(=O)O)CCC(=O)N)(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)C)CC1C=CC(O)=CC=1
InChi Key	LQRUFPWSECMCHG-YBFBXAKBSA-N
InChi Code	InChI=1S/C48H73N11O17/c1-6-24(4)39(47(74)59-19-7-8-34(59)46(73)53-28(13-16-35(50)61)41(68)54-30(48(75)76)14-17-36(51)62)58-45(72)31(20-23(2)3)56-43(70)32(21-26-9-11-27(60)12-10-26)57-42(69)29(15-18-37(63)64)52-44(71)33(22-38(65)66)55-40(67)25(5)49/h9-12,23-25,28-34,39,60H,6-8,13-22,49H2,1-5H3,(H2,50,61)(H2,51,62)(H,52,71)(H,53,73)(H,54,68)(H,55,67)(H,56,70)(H,57,69)(H,58,72)(H,63,64)(H,65,66)(H,75,76)/t24-,25-,28-,29-,30-,31-,32-,33-,34-,39-/m0/s1
Chemical Name	(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Solubility Data

Solubility (In Vitro)	H2O: 50 mg/mL (46.46 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 25 mg/mL (23.23 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.9292 mL	4.6461 mL	9.2923 mL
	5 mM	0.1858 mL	0.9292 mL	1.8585 mL
	10 mM	0.0929 mL	0.4646 mL	0.9292 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.