Deoxyguanosine triphosphate (dGTP) trisodium salt is a nucleotide precursor used in DNA synthesis in cells. In reverse transcription polymerase chain reaction (RT-PCR), deoxyguanosine triphosphate trisodium salt is utilized to amplify DNA.

Physicochemical Properties

Molecular Formula	C10H13N5NA3O13P3
Molecular Weight	573.13
Exact Mass	572.941
CAS #	93919-41-6
Related CAS #	dGTP;2564-35-4
PubChem CID	135705223
Appearance	Colorless to light yellow liquid
LogP	0.589
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	15
Rotatable Bond Count	8
Heavy Atom Count	34
Complexity	876
Defined Atom Stereocenter Count	3
SMILES	O=C1N=C(N)NC2N([C@H]3C[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)O3)C=NC1=2.[Na]
InChi Key	IWGGLKOTEOCWQP-BIHLCPNHSA-K
InChi Code	InChI=1S/C10H16N5O13P3.3Na/c11-10-13-8-7(9(17)14-10)12-3-15(8)6-1-4(16)5(26-6)2-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h3-6,16H,1-2H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,11,13,14,17);;;/q;3*+1/p-3/t4-,5+,6+;;;/m0.../s1
Chemical Name	trisodium;[[[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] hydrogen phosphate
Synonyms	2'-Deoxyguanosine-5'-triphosphate trisodium salt; dGTP trisodium salt; Deoxyguanosine triphosphate trisodium salt
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency. Cell Rep. 2020 Aug 4;32(5):107985.

Solubility Data

Solubility (In Vitro)	H2O : ~66.7 mg/mL (~116.3 mM) DMSO : < 1 mg/mL
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (174.48 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7448 mL	8.7240 mL	17.4480 mL
	5 mM	0.3490 mL	1.7448 mL	3.4896 mL
	10 mM	0.1745 mL	0.8724 mL	1.7448 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.