Cotylenin A is a phenanthroquinone compound that synergizes with vitamin K2 to induce monocyte differentiation and growth arrest, while inhibiting c-Myc expression and inducing cyclin G2 expression in human leukemia HL-60 cells. Cotylenin A can be used in acute myeloid leukemia research.

Physicochemical Properties

Molecular Formula	C33H50O11
Molecular Weight	622.74
CAS #	12708-37-1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Vitamin K2 and cotylenin A synergistically induce monocytic differentiation and growth arrest along with the suppression of c-MYC expression and induction of cyclin G2 expression in human leukemia HL-60 cells. Int J Oncol. 2015 Jun 4;47(2):473–480.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.6058 mL	8.0290 mL	16.0581 mL
	5 mM	0.3212 mL	1.6058 mL	3.2116 mL
	10 mM	0.1606 mL	0.8029 mL	1.6058 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.