LTB is a prodrug formed by coupling a glycolysis inhibitor (lonidamine) and a PD1/PDL1 blocker (BMS-1) through a thioketal bond. LTB can be further coated with the photosensitizer chlorine e6 (Ce6) to construct a co-delivery photodynamic nanoplatform (LTB-6 NPs) through self-assembly.

Physicochemical Properties

Molecular Formula	C53H59CL2N3O7S2
Molecular Weight	985.09
Synonyms	Lon-TK-BMS-1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Novel co-delivery nanomedicine for photodynamic enlarged immunotherapy by cascade immune activation and efficient Immunosuppression reversion. Bioorg Chem. 2024 Dec;153:107978.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.0151 mL	5.0757 mL	10.1514 mL
	5 mM	0.2030 mL	1.0151 mL	2.0303 mL
	10 mM	0.1015 mL	0.5076 mL	1.0151 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.