LD4172 is a PROTAC degrader that can degrade RIP kinase (RIPK1) with a DC50 at the nanomolar level. LD4172 can induce apoptosis in B16F10 cells when used in combination with TNF-α. LD4172 exhibits anti-tumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase VHL)

Physicochemical Properties

Molecular Formula	C61H75F3N10O7S
Molecular Weight	1149.37
CAS #	2782022-40-4
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Development of a RIPK1 degrader to enhance antitumor immunity. Nat Commun. 2024 Dec 16;15(1):10683.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.8700 mL	4.3502 mL	8.7004 mL
	5 mM	0.1740 mL	0.8700 mL	1.7401 mL
	10 mM	0.0870 mL	0.4350 mL	0.8700 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.