Cornuside is an iridoid glycoside extracted from the fruit of Cornus officinalis Sieb. et Zucc., a traditional oriental medicine utilized in study/research of inflammatory diseases and to promote blood circulation. Cornuside inhibits mast cell-mediated allergic reactions by downregulating MAPK and NF-κB signaling pathways. The in vivo and in vitro antiallergic effects of Cornuside suggest the potential of this active molecule for use in inflammatory allergic diseases.

Physicochemical Properties

Molecular Formula	C24H30O14
Molecular Weight	542.49
Exact Mass	542.163
CAS #	131189-57-6
Related CAS #	131189-57-6
PubChem CID	11228694
Appearance	White to off-white solid
Density	1.6±0.1 g/cm3
Boiling Point	817.6±65.0 °C at 760 mmHg
Flash Point	274.5±27.8 °C
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.648
LogP	-0.31
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	14
Rotatable Bond Count	11
Heavy Atom Count	38
Complexity	851
Defined Atom Stereocenter Count	8
SMILES	O=C(C1=CO[C@@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)[C@H](C=C)[C@@H]1CCOC(C3=CC(O)=C(O)C(O)=C3)=O)OC
InChi Key	SMTKSCGLXONVGL-UPIRYGIPSA-N
InChi Code	InChI=1S/C24H30O14/c1-3-11-12(4-5-35-21(32)10-6-14(26)17(28)15(27)7-10)13(22(33)34-2)9-36-23(11)38-24-20(31)19(30)18(29)16(8-25)37-24/h3,6-7,9,11-12,16,18-20,23-31H,1,4-5,8H2,2H3/t11-,12+,16-,18-,19+,20-,23+,24+/m1/s1
Chemical Name	methyl (2S,3R,4S)-3-ethenyl-4-[2-(3,4,5-trihydroxybenzoyl)oxyethyl]-2-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,4-dihydro-2H-pyran-5-carboxylate
Synonyms	Cornuside
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	p38 MAP kinase; NF-κB
References	[1]. Biol Pharm Bull . 2011;34(7):959-66. [2]. Pharmacology . 2009;84(3):162-70.
Additional Infomation	7-Galloylsecologanol has been reported in Cornus officinalis with data available. See also: Cornuside (annotation moved to).

Solubility Data

Solubility (In Vitro)

DMSO: ~100 mg/mL (~184.3 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (4.61 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (4.61 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (4.61 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.8434 mL	9.2168 mL	18.4335 mL
	5 mM	0.3687 mL	1.8434 mL	3.6867 mL
	10 mM	0.1843 mL	0.9217 mL	1.8434 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.