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BMS-599626 dihydrochloride is a pan-HER (human epidermal growth factor receptor) kinase inhibitor that is a small molecule. The HER1 (IC50=20 nmol/L) and HER2 (IC50=30 nmol/L) kinase activity in the HER family are the main targets of BMS-599626 dihydrochloride. BMS-599626 competes with the ATP-binding sites of HER1 and HER2 to inhibit their kinase activity. By preventing HER1 and HER2 from forming heterodimers, it can also inhibit the downstream signaling pathway. The antitumor effects of several HER1 or HER2 overexpressed tumor models can be investigated using BMS-599626 dihydrochloride [1].
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Physicochemical Properties
| Molecular Formula |
C27H29CL2FN8O3
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| Molecular Weight |
603.48
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| CAS # |
1781932-33-9
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| SMILES |
Cl.Cl.FC1=CC=CC(=C1)CN1C2C=CC(=CC=2C=N1)NC1C2=C(C)C(=CN2N=CN=1)NC(=O)OC[C@@H]1COCCN1
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Biological Activity
| References |
[1]. Preclinical antitumor activity of BMS-599626, a pan-HER kinase inhibitor that inhibits HER1/HER2 homodimer and heterodimer signaling[J]. Clinical cancer research, 2006, 12(20): 6186-6193.
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Solubility Data
| Preparing Stock Solutions |
|
1 mg |
5 mg |
10 mg |
| 1 mM |
1.6571 mL |
8.2853 mL |
16.5706 mL |
| 5 mM |
0.3314 mL |
1.6571 mL |
3.3141 mL |
| 10 mM |
0.1657 mL |
0.8285 mL |
1.6571 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles. |
