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A-16316-C is a new water-soluble basic antibiotic isolated together with antibiotic A-396-I and hygromycin B from a streptomyces strain identified as Streptoverticullium eurocidicus. The properties of the antibiotic A-16316-C were similar to those of destomycin B. But it was found that the antibiotic A-16316-C was not identical with destomycin B on the basis of NMR analysis. On acidic degradation antibiotic A-16136-C gave N, N'-dimethyl-2-deoxystreptamine, destomic acid and D-mannose. The gross structure for antibiotic A-16136-C was deduced from chemical reactions and spectral data.
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Physicochemical Properties
| Molecular Formula |
C21H39N3O13
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| Molecular Weight |
541.546667337418
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| Exact Mass |
541.248
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| CAS # |
11005-98-4
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| Related CAS # |
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| PubChem CID |
197125
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| Appearance |
Typically exists as solid at room temperature
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| Density |
1.61g/cm3
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| Boiling Point |
889.8ºC at 760 mmHg
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| Flash Point |
491.9ºC
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| Vapour Pressure |
0mmHg at 25°C
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| Index of Refraction |
1.653
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| LogP |
-6.1
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| Hydrogen Bond Donor Count |
11
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| Hydrogen Bond Acceptor Count |
16
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| Rotatable Bond Count |
7
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| Heavy Atom Count |
37
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| Complexity |
755
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| Defined Atom Stereocenter Count |
0
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| SMILES |
OCC(C1C(O)C(O)C(O)C2(OC3C(C(OC(OC4C(O)C(NC)CC(NC)C4O)C3O2)CO)O)O1)N
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| InChi Key |
XQRJFJIKNNEPNI-UHFFFAOYSA-N
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| InChi Code |
InChI=1S/C21H39N3O13/c1-23-7-3-8(24-2)11(28)16(10(7)27)34-20-18-17(12(29)9(5-26)33-20)36-21(37-18)19(32)14(31)13(30)15(35-21)6(22)4-25/h6-20,23-32H,3-5,22H2,1-2H3
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| Chemical Name |
6'-(1-amino-2-hydroxyethyl)-4-[2,6-dihydroxy-3,5-bis(methylamino)cyclohexyl]oxy-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2'-oxane]-3',4',5',7-tetrol
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| Synonyms |
| A 16316-C; A16316-C; A-16316-C |
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| HS Tariff Code |
2934.99.9001
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| Storage |
Powder-20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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| Shipping Condition |
Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)
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Biological Activity
| ln Vitro |
In vitro activity:
Kinase Assay:
Cell Assay: |
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| ln Vivo |
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| Animal Protocol |
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| References |
J Antibiot (Tokyo).1975 Apr;28(4):260-5.
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| Additional Infomation |
AB-74 is an amino cyclitol.
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Solubility Data
| Solubility (In Vitro) |
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| Solubility (In Vivo) |
(Please use freshly prepared in vivo formulations for optimal results.)
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| Preparing Stock Solutions |
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1 mg |
5 mg |
10 mg |
| 1 mM |
1.8466 mL |
9.2328 mL |
18.4655 mL |
| 5 mM |
0.3693 mL |
1.8466 mL |
3.6931 mL |
| 10 mM |
0.1847 mL |
0.9233 mL |
1.8466 mL |
*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles. |
