7-Chloro-4-(piperazin-1-yl)quinolone is an important scaffold in active molecular chemistry. 7-Chloro-4-(piperazin-1-yl)quinolone is a potent sirtuin inhibitor that also inhibits serotonin uptake (IC50 of 50 μM). 7-Chloro-4-(piperazin-1-yl)quinolone displays antimalarial activity against Plasmodium falciparum D10 and K1 strains with IC50 of 1.18 μM and 0.97 μM, respectively.

Physicochemical Properties

Molecular Formula	C13H14CLN3
Molecular Weight	247.72
Exact Mass	247.088
CAS #	837-52-5
PubChem CID	738389
Appearance	White to yellow solid powder
Density	1.257 g/cm3
Boiling Point	433.5ºC at 760 mmHg
Melting Point	113-116ºC
Flash Point	216ºC
Index of Refraction	1.636
LogP	2.691
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Heavy Atom Count	17
Complexity	255
Defined Atom Stereocenter Count	0
InChi Key	DNXNPMDUDGUXOB-UHFFFAOYSA-N
InChi Code	InChI=1S/C13H14ClN3/c14-10-1-2-11-12(9-10)16-4-3-13(11)17-7-5-15-6-8-17/h1-4,9,15H,5-8H2
Chemical Name	7-chloro-4-piperazin-1-ylquinoline
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Plasmodium
References	[1]. Structural and biological survey of 7-chloro-4-(piperazin-1-yl)quinoline and its derivatives. Drug Dev Res. 2020 Nov;81(7):786-802.

Solubility Data

Solubility (In Vitro)

DMSO : 16.67 mg/mL (67.29 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 1.67 mg/mL (6.74 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 1.67 mg/mL (6.74 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 1.67 mg/mL (6.74 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.0368 mL	20.1841 mL	40.3682 mL
	5 mM	0.8074 mL	4.0368 mL	8.0736 mL
	10 mM	0.4037 mL	2.0184 mL	4.0368 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.