4-Methylcinnamic acid, a cinnamic acid analog, may be used as an intervention catalyst to overcome antifungal resistance. 4-Methylcinnamic acid can increase the effectiveness of cell wall destroying agents.

Physicochemical Properties

Molecular Formula	C10H10O2
Molecular Weight	162.19
Exact Mass	162.068
CAS #	1866-39-3
PubChem CID	731767
Appearance	Typically exists as solid at room temperature
Density	1.1±0.1 g/cm3
Boiling Point	300.6±11.0 °C at 760 mmHg
Melting Point	196-198 °C(lit.)
Flash Point	206.1±10.2 °C
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.603
LogP	2.87
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	2
Heavy Atom Count	12
Complexity	176
Defined Atom Stereocenter Count	0
SMILES	O([H])C(/C(/[H])=C(\[H])/C1C([H])=C([H])C(C([H])([H])[H])=C([H])C=1[H])=O
InChi Key	RURHILYUWQEGOS-VOTSOKGWSA-N
InChi Code	InChI=1S/C10H10O2/c1-8-2-4-9(5-3-8)6-7-10(11)12/h2-7H,1H3,(H,11,12)/b7-6+
Chemical Name	(E)-3-(4-methylphenyl)prop-2-enoic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Kim JH, et, al. Cinnamic Acid Analogs as Intervention Catalysts for Overcoming Antifungal Tolerance. Molecules. 2017 Oct 21;22(10):1783.
Additional Infomation	4-Methylcinnamic acid is a member of cinnamic acids.

Solubility Data

Solubility (In Vitro)

DMSO : 100 mg/mL (616.56 mM)

Solubility (In Vivo)

Solubility in Formulation 1: 2.5 mg/mL (15.41 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (15.41 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.1656 mL	30.8280 mL	61.6561 mL
	5 mM	1.2331 mL	6.1656 mL	12.3312 mL
	10 mM	0.6166 mL	3.0828 mL	6.1656 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.