(1R)-α-Pinene is a volatile monoterpene with antimicrobial activity. (1R)-α-Pinene reduces the growth of Bacillus cereus populations and displays mosquito repellent effects.

Physicochemical Properties

Molecular Formula	C10H16
Molecular Weight	136.2340
Exact Mass	136.125
CAS #	7785-70-8
PubChem CID	82227
Appearance	Colorless to light yellow liquid
Density	0.9±0.1 g/cm3
Boiling Point	157.9±7.0 °C at 760 mmHg
Melting Point	-62ºC
Flash Point	32.2±0.0 °C
Vapour Pressure	3.5±0.1 mmHg at 25°C
Index of Refraction	1.479
LogP	4.37
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	0
Rotatable Bond Count	0
Heavy Atom Count	10
Complexity	186
Defined Atom Stereocenter Count	2
SMILES	C1(C([H])([H])[H])(C([H])([H])[H])[C@@]2([H])C(C([H])([H])[H])=C([H])C([H])([H])[C@]1([H])C2([H])[H]
InChi Key	GRWFGVWFFZKLTI-RKDXNWHRSA-N
InChi Code	InChI=1S/C10H16/c1-7-4-5-8-6-9(7)10(8,2)3/h4,8-9H,5-6H2,1-3H3/t8-,9-/m1/s1
Chemical Name	(1R,5R)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Sciadopitys verticillata Resin: Volatile Components and Impact on Plant Pathogenic and Foodborne Bacteria. Molecules. 2019 Oct 19;24(20):3767. [2]. Repellency of α-pinene against the house fly, Musca domestica. Phytochemistry. 2015 Sep;117:469-475.
Additional Infomation	(+)-alpha-pinene is the (+)-enantiomer of alpha-pinene. It has a role as a plant metabolite and a human metabolite. It is an enantiomer of a (-)-alpha-pinene. (+)-alpha-Pinene has been reported in Artemisia xerophytica, Salvia officinalis, and other organisms with data available.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (734.05 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (18.35 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (18.35 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (18.35 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	7.3405 mL	36.7026 mL	73.4053 mL
	5 mM	1.4681 mL	7.3405 mL	14.6811 mL
	10 mM	0.7341 mL	3.6703 mL	7.3405 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.