| Description | Xanthine oxidoreductase-IN-4 is an orally active xanthine oxidoreductase (XOR) inhibitor that inhibits XOR with an IC50 value of 29.3 nM.Xanthine oxidoreductase-IN-4 can be used to study hyperuricemia. |
| In vitro | Xanthine Oxidoreductase - IN-4 (compound IIIc) has inhibitory activity against XOR (IC50=29.3 nM).[1] |
| In vivo | Xanthine oxidoreductase-IN-4（5mg/kg；口服）在通过草酸钾/次黄嘌呤诱导的急性高尿酸血症模型中，展现了显著的降低尿酸效果。[1] |
| Target activity | XOR:29.3 nM |
| molecular weight | 309.32 |
| Molecular formula | C16H15N5O2 |
| CAS | 1026587-58-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (145.48 mM) |
| References | 1. Peng W, et al. Design, synthesis, and evaluation of tricyclic compounds containing phenyl-tetrazole as XOR inhibitors. Eur J Med Chem. 2023;246:114947. |