| Description | VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity. |
| molecular weight | 266.23 |
| Molecular formula | C14H7FN4O |
| CAS | 327056-22-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: 6.0 mg/mL (22.5 mM) DMSO: 9 mg/mL (33.81 mM), Sonication is recommended. |
| References | 1. Rodriguez AL, et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. Mol Pharmacol. 2010 Dec;78(6):1105-23. |