| Description | gamma-DGG acetate(6729-55-1 free base) (γ-D-Glutamylglycine) is a competitive blocker of AMPA receptor. |
| In vitro | gamma-DGG acetate 是对兴奋性突触后电位(e.p.s.p.s)的高效拮抗剂。它的作用是可逆的，并且不会引起颗粒细胞被动膜性质的任何改变，也不会影响e.p.s.p.的表观逆转电位。在较高谷氨酸浓度下，gamma-DGG的阻断作用减弱。当浴中含有gamma-DGG (200-400 μM)时，会使微小EPSC (mEPSC)的幅度降低26±2%（n=5个突触），并且使mEPSC幅度分布和累积概率曲线向左移动[1]。量子分析显示，e.p.s.p.的减少与量子大小的减少相一致，而不是量子内容，这证实了gamma-DGG作用的部位是突触后的[2]。 |
| Synonyms | γDGG, γ-D-Glutamylglycine |
| molecular weight | 264.23 |
| Molecular formula | C9H16N2O7 |
| CAS | 2935387-13-4 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Slightly soluble |
| References | 1. Wu XS, et al. The origin of quantal size variation: vesicular glutamate concentration plays a significant role. J Neurosci. 2007 Mar 14;27(11):3046-56. 2. Crunelli V, et al. Blockade of amino acid-induced depolarizations and inhibition of excitatory post-synaptic potentials in rat dentate gyrus. J Physiol. 1983 Aug;341:627-40. |