| Description | Tubulin/HDAC-IN-3 (compound 12a) serves as a potent dual inhibitor of tubulin polymerization and HDAC1/8, exhibiting IC50 values of 5.4 μM for tubulin polymerization, and 0.155 and 0.177 μM for HDAC1 and HDAC8, respectively. Its mechanism of action includes obstructing the cell cycle, triggering apoptosis, and suppressing colony formation [1]. |
| In vitro | Tubulin/HDAC-IN-3 (化合物12a) 对BE-(2)-C、A549、U87MG 和 HCT116这四种肿瘤细胞系展现出显著的体外抗增殖效果，其IC 50 值分别为0.017±0.002、0.053±0.003、0.056±0.005和0.051±0.003 μM [1]。 |
| In vivo | Tubulin/HDAC-IN-3（化合物12a）（25 mg/kg，q3d IP）在小鼠体内显著展现抗肿瘤活性[1]。 |
| Target activity | HDAC1:0.155 μM, HDAC6:1.037 μM, HDAC8:0.177 μM |
| molecular weight | 552.53 |
| Molecular formula | C28H28N2O10 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |