| Description | TG 100713 is a pan-PI3K inhibitor against PI3Kγ, PI3Kδ, PI3Kα and PI3Kβ with IC50 of 50 nM, 24 nM, 165 nM and 215 nM, respectively. |
| In vitro | TG 100713 也强烈抑制EC增殖。[1] |
| Cell experiments | Human umbilical vein EC plated in 96-well cluster plates (5,000 cells/well) are cultured in assay medium (containing 0.5% serum and 50 ng/ml VEGF) in the presence or absence of test compounds (10 μM), and cell numbers are quantified by XTT assay.(Only for Reference) |
| Target activity | PI3Kγ:50 nM, PI3Kα:165 nM, PI3Kβ:215 nM, PI3Kδ:24 nM |
| Synonyms | TG100713 |
| molecular weight | 254.25 |
| Molecular formula | C12H10N6O |
| CAS | 925705-73-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 2.5 mg/mL (10 mM) |
| References | 1. Doukas J et al. Proc Natl Acad Sci U S A, 2006, 103(52), 19866-19871. |