| Description | PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM). |
| In vivo | 对于PI3K的不同亚型,PIK-294均有抑制作用,如p110β, p110δ和p110γ,但对于p110α选择性很低。 |
| Target activity | p110δ:10 nM |
| Synonyms | PIK294 |
| molecular weight | 489.53 |
| Molecular formula | C28H23N7O2 |
| CAS | 900185-02-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | Ethanol: < 1 mg/mL (insoluble or slightly soluble) DMSO: 91 mg/mL (185.9 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) |
| References | 1. Knight ZA, et al. Cell. 2006, 125(4), 733-747. 2. Bobrovnikova-Marjon E, et al. Mol Cell Biol. 2012, 32(12), 2268-2278. |