| Description | PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). . |
| In vitro | PI4KIIIbeta-IN-9对PI3KC2γ（IC50约1 μM）、PI3Kα（约2 μM）和PI4KIIIα（约2.6 μM）表现出弱抑制作用，并在高达20 μM的浓度下对PI4K2α、PI4K2β和PI3Kβ的抑制率均<50%。PI4KIIIbeta-IN-9呈新月形状，与PI4KIIIβ的活性位点相吻合，与PI4KIIIβ有广泛接触。此外，PI4KIIIbeta-IN-9还能以IC50为152 nM和1046 nM分别抑制PI3Kδ和PI3Kγ。 |
| Target activity | PI3Kγ:1046 nM, PI4KIIIα:2.6 μM, PI4KIIIβ:7 nM, PI3Kα:2 μM, PI3KC2γ:1 μM, PI3Kδ:152 nM |
| molecular weight | 487.59 |
| Molecular formula | C23H25N3O5S2 |
| CAS | 1429624-84-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 4.88 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Rutaganira FU, et al. Design and Structural Characterization of Potent and Selective Inhibitors of Phosphatidylinositol 4 Kinase IIIβ. J Med Chem. 2016 Mar 10;59(5):1830-9. |