| Description | TASK-1-IN-1 is a potent and selective inhibitor of TASK-1 (Potassium Channel) (IC50: 148 nM).TASK-1-IN-1 has a reduced inhibitory effect on the TASK-3 channel with an IC50 of 1750 nM.TASK-1-IN-1 has anticancer effects. |
| In vitro | TASK-1-IN-1在MCF-7癌细胞系中展现了对细胞增殖和生存度的抑制效果。然而，在TASK-1基因敲除的MCF-7细胞中未观察到这些效果，表明其对TASK-1通道的特异性作用。[1] |
| Target activity | TASK1:148 nM, TASK3:1750 nM |
| molecular weight | 344.41 |
| Molecular formula | C22H20N2O2 |
| CAS | 600125-11-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: < 1mg/ml (insoluble） |
| References | 1. Arévalo B, et al. Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability. J Med Chem. 2022;65(22):15014-15027. |