| Description | ZM 226600 is an ATP-sensitive potassium channel opener with an EC50 value of 500 nM. ZM226600 has an inhibitory effect on spontaneous bladder activity. |
| In vitro | ZM226600 (1 μM, 30 min) inhibited spontaneous bladder activity.[1] |
| In vivo | ZM226600 (10-1000 nmol/kg, i.v.) did not significantly alter the heart rate of anesthetized rats.[1] |
| Target activity | K+ channel:500 nM(EC50) |
| molecular weight | 373.35 |
| Molecular formula | C16H14F3NO4S |
| CAS | 147695-92-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 90.0 mg/mL (241.0 mM) |
| References | 1. Pinna C, et al. Effect of the ATP-sensitive potassium channel opener ZM226600 on cystometric parameters in rats with ligature-intact, partial urethral obstruction. Eur J Pharmacol. 2005 ; 516(1):71-77. 2. Grant TL, et al. Anilide tertiary carbinols: a novel series of K+ channel openers. Trends Pharmacol Sci. 1994 ; 15(11):402-404. 3. Jansen-Olesen I, et al. Characterization of K(ATP)-channels in rat basilar and middle cerebral arteries: studies of vasomotor responses and mRNA expression. Eur J Pharmacol. 2005 ; 523(1-3):109-118. |