| Description | QO-40 is a KCNQ2/3 potassium channels activator. |
| In vitro | QO-40 显著增强在中国地鼠卵巢细胞中表达的 KCNQ2/3 通道，并将半最大激活电压（V(1/2)）向超极化方向移动。V(1/2) 的负移是浓度依赖性的。该化合物显著减慢了 KCNQ2/3 通道的激活和去激活动力学。 |
| molecular weight | 377.75 |
| Molecular formula | C18H11ClF3N3O |
| CAS | 1259536-70-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 25 mg/mL (66.18 mM) |
| References | 1. Jia C , Qi J , Zhang F , et al. Activation of KCNQ2/3 Potassium Channels by Novel Pyrazolo[1,5-a]pyrimidin-7(4H)-One Derivatives[J]. Pharmacology, 2011, 87(5-6):297-310. |