| Description | STING-IN-2 (C-170) is a potent and covalent inhibitor of STING. C-170 efficiently inhibits both mouse STING (mmSTING) and human STING (hsSTING). It can be used for autoinflammatory disease research. |
| In vitro | In THP-1 cells, pretreated with STING-IN-2 (C-170;?0.5 μM) and stimulated with cGAMP.?STING-IN-2 (C-170) treatment decreases the IFNB1 and TNF mRNA levels, and also reduces the p-TBK1 levels |
| Synonyms | C-170 |
| molecular weight | 288.3 |
| Molecular formula | C15H16N2O4 |
| CAS | 346691-38-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 22.5 mg/mL (78.04 mM) |
| References | 1. Simone M Haag, et al. Targeting STING with covalent small-molecule inhibitors. Nature. 2018 Jul;559(7713):269-273. |