| Description | Sirt1/2-IN-3 (compound PS9) serves as a dual inhibitor of SIRT1/2, exhibiting IC50 values of 1.4 μM (SIRT1) and 2.0 μM (SIRT2), respectively. This compound effectively inhibits p53 deacetylation while simultaneously elevating p53 and α-tubulin acetylation levels. Additionally, Sirt1/2-IN-3 promotes apoptosis and exhibits antiproliferative effects on human leukemia cell lines [1]. |
| In vitro | Sirt1/2-IN-3 (compound hsa55) (5 μM; 48 h) 在多种肿瘤细胞中引发凋亡，其半抑制浓度(IC 50)分别为：MV4-11细胞为6.5 μM、MOLM-13细胞为9.2 μM、THP1细胞为27.2 μM、Jurkat细胞为17.4 μM [1]。此外，Sirt1/2-IN-3在100 μM浓度和30分钟处理下可降低SIRT1及SIRT2蛋白的热稳定性，并能在25 μM及30 μM浓度，24小时处理后提高MOLM-13细胞中p53和α微管蛋白的乙酰化水平 [1]。 |
| molecular weight | 363.82 |
| Molecular formula | C17H14ClNO4S |
| CAS | 301313-42-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |