| Description | Sirt1/2-IN-4 (compound PS3) is a potent triple inhibitor of SIRT1, SIRT2, and SIRT3, exhibiting IC50 values of 1.2 μM (SIRT1), 1.9 μM (SIRT2), and 18.6 μM (SIRT3), respectively. It effectively inhibits p53 deacetylation, indicating potential anticancer properties [1]. |
| In vitro | Sirt1/2-IN-4（化合物PS3）（5 μM；48小时）在多种肿瘤细胞中诱导凋亡作用，其半数抑制浓度（IC 50）分别为6.5 μM（MV4-11）、9.2 μM（MOLM-13）、27.2 μM（THP1）、以及17.4 μM（Jurkat）[1]。 |
| molecular weight | 440.54 |
| Molecular formula | C21H20N4O3S2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |