| Description | Sirt1/2-IN-2 (compound hsa55) serves as a dual inhibitor for SIRT1 with an IC50 of 1.8 μM and SIRT2 with an IC50 of 2.4 μM, respectively. It effectively inhibits p53 deacetylation while enhancing the acetylation of p53 and α-tubulin. The compound also promotes apoptosis and exhibits anti-proliferative effects on human leukemia cell lines [1]. |
| In vitro | Sirt1/2-IN-2 (化合物hsa55) (5 μM; 48 h) 能够引起多种肿瘤细胞的凋亡，不同细胞线的半数抑制浓度（IC50）分别为：13 μM (MV4-11)、11.5 μM (MOLM-13)、34.4 μM (THP1)、及27.5 μM (Jurkat) [1]。此外，Sirt1/2-IN-2 (100 μM; 30 min) 可以减少 SIRT1 和 SIRT2 蛋白的热稳定性，并在 (25 μM、30 μM; 24 h) 的处理下令 MOLM-13 细胞中 p53 及 α-tubulin 的乙酰化水平升高 [1]。 |
| molecular weight | 398.46 |
| Molecular formula | C18H14N4O3S2 |
| CAS | 670267-73-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |